Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 10/20 | 0.39 |
| ▸ | EEF2K | O00418 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.35 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.35 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.35 |
| ▸ | GUSB | P08236 | 2/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794615 | 0.98 | EEF2K (0.37) | CCR5EEF2KMEN1APAF1NPC1 | |
| SCHEMBL8453756 | 0.98 | EEF2K (0.37) | CCR5EEF2KMEN1APAF1NPC1 | |
| SCHEMBL28398124 | 0.98 | EEF2K (0.37) | CCR5EEF2KMEN1APAF1NPC1 | |
| SCHEMBL5794438 | 0.98 | EEF2K (0.37) | CCR5EEF2KMEN1APAF1NPC1 | |
| SCHEMBL5796690 | 0.98 | EEF2K (0.37) | CCR5EEF2KMEN1APAF1NPC1 | |
| SCHEMBL6383372 | 0.98 | EEF2K (0.37) | CCR5EEF2KMEN1APAF1NPC1 | |
| SCHEMBL5797197 | 0.98 | EEF2K (0.37) | CCR5EEF2KMEN1APAF1NPC1 | |
| SCHEMBL2927391 | 0.98 | EEF2K (0.37) | CCR5EEF2KMEN1APAF1NPC1 | |
| Bromide SCHEMBL5993515 | 0.96 | MEN1 (0.40) | CCR5EEF2KMEN1APAF1NPC1 | |
| SCHEMBL5795512 | 0.96 | EEF2K (0.35) | CCR5EEF2KMEN1APAF1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252870-B2 | Cure system of halogenated elastomer compositions, a curable halogenated elastomer composition, and a method for curing halogenated elastomer compositions | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-08-28 | — | — | US | claimed |
| US-7964110-B2 | Cure system for halogenated elastomer compositions, a curable halogenated elastomer composition, and a method for curing halogenated elastomer compositions | DOW GLOBAL TECHNOLOGIES LLC (US) | 2011-06-21 | — | — | US | claimed |
| EP-1861460-B1 | VULCANIZABLE CHLORINATED ELASTOMER COMPOSITIONS WITH IMPROVED PROCESSING SAFETY AND CURE RATE | DOW GLOBAL TECHNOLOGIES INC (US) | 2010-09-29 | — | — | EP | claimed |
| US-7750088-B2 | Cure system for chlorinated elastomer compositions and a method of curing chlorinated elastomer compositions | DOW GLOBAL TECHNOLOGIES (US) | 2010-07-06 | — | — | US | claimed |
| US-20100010152-A1 | CURE SYSTEM OF HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTOMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES LLC | 2010-01-14 | — | — | US | claimed |
| EP-1960462-B1 | A CURE SYSTEM FOR HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTROMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES INC (US) | 2010-01-13 | — | — | EP | claimed |
| US-20090326143-A1 | CURE SYSTEM FOR HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTOMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES LLC | 2009-12-31 | — | — | US | claimed |
| US-7612149-B2 | Vulcanizable chlorinated elastomer compositions with improved processing safety and cure rate | DOW GLOBAL TECHNOLOGIES INC. (US) | 2009-11-03 | — | — | US | claimed |
| EP-2059557-B1 | A CURE SYSTEM FOR HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTOMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-2826816-A1 | A curable halogenated elastomer composition and a method for curing halogenated elastomer compositions | Dow Global Technologies LLC (US) | 2015-01-21 | — | — | EP | disclosed |
| US-8252870-B2 | Cure system of halogenated elastomer compositions, a curable halogenated elastomer composition, and a method for curing halogenated elastomer compositions | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-08-28 | — | — | US | disclosed |
| US-7964110-B2 | Cure system for halogenated elastomer compositions, a curable halogenated elastomer composition, and a method for curing halogenated elastomer compositions | DOW GLOBAL TECHNOLOGIES LLC (US) | 2011-06-21 | — | — | US | disclosed |
| EP-1861460-B1 | VULCANIZABLE CHLORINATED ELASTOMER COMPOSITIONS WITH IMPROVED PROCESSING SAFETY AND CURE RATE | DOW GLOBAL TECHNOLOGIES INC (US) | 2010-09-29 | — | — | EP | disclosed |
| US-7750088-B2 | Cure system for chlorinated elastomer compositions and a method of curing chlorinated elastomer compositions | DOW GLOBAL TECHNOLOGIES (US) | 2010-07-06 | — | — | US | disclosed |
| US-20100010152-A1 | CURE SYSTEM OF HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTOMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES LLC | 2010-01-14 | — | — | US | disclosed |
| EP-1960462-B1 | A CURE SYSTEM FOR HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTROMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES INC (US) | 2010-01-13 | — | — | EP | disclosed |
| US-20090326143-A1 | CURE SYSTEM FOR HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTOMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES LLC | 2009-12-31 | — | — | US | disclosed |
| US-7612149-B2 | Vulcanizable chlorinated elastomer compositions with improved processing safety and cure rate | DOW GLOBAL TECHNOLOGIES INC. (US) | 2009-11-03 | — | — | US | disclosed |
| US-20080255313-A1 | Cure System for Chlorinated Elastomer Compositions and a Method of Curing Chlorinated Elastomer Compositions | LAAKSO RAYMOND L | 2008-10-16 | — | — | US | disclosed |
| US-20060205889-A1 | cure system composition consisting of a crosslinking agent 2-mercapto-1,3,4-thiadiazole-5-thiobenzoate and accelerators 1-butyl-3-methylimidazolinium chloride; for curing chlorinated polyethylene | DOW GLOBAL TECHNOLOGIES INC. (US) | 2006-09-14 | — | — | US | disclosed |