Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 0.66 |
| ▸ | HTR2B | P41595 | 10/20 | 0.66 |
| ▸ | HTR2A | P28223 | 7/20 | 0.66 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19262111 | 0.81 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL16585368 | 0.81 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL18019012 | 0.81 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL18018994 | 0.81 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL16585369 | 0.81 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL23993579 | 0.81 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL13591154 | 0.81 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL6582897 | 0.81 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL18016880 | 0.80 | HTR2C (0.58) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL18016878 | 0.80 | HTR2C (0.58) | HTR2CHTR2BHTR2ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101415713-A | New spiro [imidazolidine-4, 3'-indole]-2,2',5 (1'H)-trione useful for the treatment of vanilloid receptor 1-related disorders | ASTRAZENECA AB (SE) | 2009-04-22 | — | — | CN | claimed |
| EP-3312292-A1 | LUMINOGENIC AND FLUOROGENIC COMPOUNDS AND METHODS TO DETECT MOLECULES OR CONDITIONS | Promega Corporation (US) | 2018-04-25 | — | — | EP | disclosed |
| CN-101415713-A | New spiro [imidazolidine-4, 3'-indole]-2,2',5 (1'H)-trione useful for the treatment of vanilloid receptor 1-related disorders | ASTRAZENECA AB (SE) | 2009-04-22 | — | — | CN | disclosed |