Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 0.63 |
| ▸ | HTR2B | P41595 | 11/20 | 0.63 |
| ▸ | HTR2A | P28223 | 8/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20080189 | 0.81 | HTR2C (0.66) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL18019012 | 0.79 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL18018994 | 0.79 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL19262111 | 0.79 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL16585369 | 0.79 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL23993579 | 0.79 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL16585368 | 0.79 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL13591154 | 0.79 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 | |
| SCHEMBL27483145 | 0.79 | HTR2A (0.44) | HTR2CHTR2BHTR2ASLC6A3 | |
| SCHEMBL6585775 | 0.78 | HTR2C (0.63) | HTR2CHTR2BHTR2ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390354-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | Amgen Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002083653-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |