Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.31 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20084976 | 0.91 | HPGD (0.38) | HPGDLMNAALDH1A1NPSR1CYP2C9 | |
| SCHEMBL20085151 | 0.88 | HPGD (0.36) | HPGDLMNAALDH1A1NPSR1CYP2C9 | |
| SCHEMBL20084345 | 0.87 | HPGD (0.36) | HPGDLMNAALDH1A1NPSR1CYP2C9 | |
| SCHEMBL20085353 | 0.85 | HPGD (0.41) | HPGDLMNAALDH1A1NPSR1CYP2C9 | |
| SCHEMBL20084283 | 0.85 | HPGD (0.35) | HPGDLMNAALDH1A1NPSR1CYP2C9 | |
| SCHEMBL20085209 | 0.84 | HPGD (0.39) | HPGDLMNAALDH1A1NPSR1CYP2C9 | |
| SCHEMBL20084762 | 0.82 | HPGD (0.35) | HPGDLMNAALDH1A1NPSR1CYP2C9 | |
| SCHEMBL20084721 | 0.82 | CYP2C9 (0.38) | HPGDLMNAALDH1A1NPSR1CYP2C9 | |
| SCHEMBL21970629 | 0.82 | RAB9A (0.37) | HPGDLMNAALDH1A1NPSR1CYP2C9 | |
| SCHEMBL20085328 | 0.82 | RAB9A (0.39) | HPGDLMNAALDH1A1NPSR1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312172-B1 | AMINOPYRAZOLE DERIVATIVES USEFUL AS SRC KINASE INHIBITORS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2020-05-06 | — | — | EP | disclosed |
| EP-3312172-A1 | AMINOPYRAZOLE DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-04-25 | — | — | EP | disclosed |