SCHEMBL2008752

SCHEMBL2008752

C[Si](C)(/C=C/CCCC#N)c1ccccc1CO

nearest known ligand 0.30

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ENPP1 P22413 1/20 0.30
HIF1A Q16665 1/20 0.30
EPAS1 Q99814 1/20 0.30
APOBEC3G Q9HC16 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2010463 1.00 ENPP1 (0.30) ENPP1HIF1AEPAS1APOBEC3G
SCHEMBL2004589 0.81 FAAH (0.39)
SCHEMBL2004591 0.81 FAAH (0.39)
SCHEMBL12572228 0.78 APOBEC3G (0.30) APOBEC3G
SCHEMBL2004176 0.73 APOBEC3G (0.39) APOBEC3G
SCHEMBL2004175 0.73 APOBEC3G (0.39) APOBEC3G
SCHEMBL1998378 0.69 APOBEC3G (0.36) HIF1AAPOBEC3G
SCHEMBL2007121 0.68 APOBEC3G (0.41) APOBEC3G
SCHEMBL2006118 0.66 APOBEC3G (0.39) APOBEC3G
SCHEMBL9206225 0.65 APOBEC3G (0.48) APOBEC3G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7960571-B2 Silicon-based cross-coupling reagent and production method of organic compound using the same KYOTO UNIVERSITY (JP) 2011-06-14 US disclosed
US-20090069577-A1 Silicon-Based Cross-Coupling Reagent and Production Method of Organic Compound Using the Same KYOTO UNIVERSITY (JP) 2009-03-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090069577-A1 Silicon-Based Cross-Coupling Reagent and Production Method of Organic Compound Using the Same DNMT1, TET3, CTCF ENPP1 2496/4885HIF1A 2275/4885EPAS1 4776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.