Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.64 |
| ▸ | CASP7 | P55210 | 3/20 | 0.62 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MDM4 | O15151 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.62 |
| ▸ | VDR | P11473 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.62 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.62 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.62 |
| ▸ | ST3GAL1 | Q11201 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26403321 | 1.00 | GPBAR1 (0.64) | GPBAR1CASP7EPHA2TP53MAPK1 | |
| SCHEMBL20087694 | 1.00 | GPBAR1 (0.64) | GPBAR1CASP7EPHA2TP53MAPK1 | |
| SCHEMBL25479009 | 1.00 | GPBAR1 (0.64) | GPBAR1CASP7EPHA2TP53MAPK1 | |
| SCHEMBL19430542 | 1.00 | GPBAR1 (0.64) | GPBAR1CASP7EPHA2TP53MAPK1 | |
| SCHEMBL20088118 | 0.91 | ST6GAL1 (0.67) | GPBAR1CASP7EPHA2TP53MAPK1 | |
| SCHEMBL19430280 | 0.86 | GRIN2B (0.54) | GPBAR1 | |
| SCHEMBL19430279 | 0.84 | GPBAR1 (0.63) | GPBAR1MAPK1HSD17B10CYP3A4MAPT | |
| SCHEMBL20087704 | 0.84 | GRIN2B (0.63) | GPBAR1CASP7EPHA2TP53MAPK1 | |
| SCHEMBL20087595 | 0.84 | GRIN2B (0.63) | GPBAR1CASP7EPHA2TP53MAPK1 | |
| SCHEMBL19430539 | 0.83 | GRIN2A (0.56) | GPBAR1EPHA2HSD17B10TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4252848-A2 | OXYSTEROLS AND METHODS OF USE THEREOF | Sage Therapeutics, Inc. (US) | 2023-10-04 | — | — | EP | disclosed |
| EP-3529257-B1 | OXYSTEROLS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS INC (US) | 2023-05-10 | — | — | EP | disclosed |
| WO-2018075699-A1 | OXYSTEROLS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. (US) | 2018-04-26 | — | — | WO | disclosed |