Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.51 |
| ▸ | CCR5 | P51681 | 8/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2928577 | 0.98 | EEF2K (0.52) | EEF2KCCR5MEN1KMT2AGNAI3 | |
| SCHEMBL5793438 | 0.98 | EEF2K (0.52) | EEF2KCCR5MEN1KMT2AGNAI3 | |
| SCHEMBL5793435 | 0.98 | EEF2K (0.52) | EEF2KCCR5MEN1KMT2AGNAI3 | |
| SCHEMBL5796045 | 0.98 | EEF2K (0.52) | EEF2KCCR5MEN1KMT2AGNAI3 | |
| SCHEMBL5796998 | 0.98 | EEF2K (0.52) | EEF2KCCR5MEN1KMT2AGNAI3 | |
| Iodide SCHEMBL28957905 | 0.96 | EEF2K (0.55) | EEF2KCCR5MEN1KMT2AGNAI3 | |
| Iodide SCHEMBL11780581 | 0.96 | EEF2K (0.55) | EEF2KCCR5MEN1KMT2AGNAI3 | |
| Water SCHEMBL11786342 | 0.96 | EEF2K (0.51) | EEF2KCCR5MEN1KMT2AGNAI3 | |
| Bromide SCHEMBL11783405 | 0.96 | EEF2K (0.51) | EEF2KCCR5MEN1KMT2AGNAI3 | |
| SCHEMBL5796364 | 0.96 | EEF2K (0.50) | EEF2KCCR5MEN1KMT2AGNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252870-B2 | Cure system of halogenated elastomer compositions, a curable halogenated elastomer composition, and a method for curing halogenated elastomer compositions | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-08-28 | — | — | US | claimed |
| US-7964110-B2 | Cure system for halogenated elastomer compositions, a curable halogenated elastomer composition, and a method for curing halogenated elastomer compositions | DOW GLOBAL TECHNOLOGIES LLC (US) | 2011-06-21 | — | — | US | claimed |
| EP-1861460-B1 | VULCANIZABLE CHLORINATED ELASTOMER COMPOSITIONS WITH IMPROVED PROCESSING SAFETY AND CURE RATE | DOW GLOBAL TECHNOLOGIES INC (US) | 2010-09-29 | — | — | EP | claimed |
| US-7750088-B2 | Cure system for chlorinated elastomer compositions and a method of curing chlorinated elastomer compositions | DOW GLOBAL TECHNOLOGIES (US) | 2010-07-06 | — | — | US | claimed |
| US-20100010152-A1 | CURE SYSTEM OF HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTOMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES LLC | 2010-01-14 | — | — | US | claimed |
| EP-1960462-B1 | A CURE SYSTEM FOR HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTROMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES INC (US) | 2010-01-13 | — | — | EP | claimed |
| US-20090326143-A1 | CURE SYSTEM FOR HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTOMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES LLC | 2009-12-31 | — | — | US | claimed |
| US-7612149-B2 | Vulcanizable chlorinated elastomer compositions with improved processing safety and cure rate | DOW GLOBAL TECHNOLOGIES INC. (US) | 2009-11-03 | — | — | US | claimed |
| EP-2059557-A2 | A CURE SYSTEM FOR HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTOMER COMPOSITIONS | Dow Global Technologies Inc. (US) | 2009-05-20 | — | — | EP | claimed |
| EP-1960462-A1 | A CURE SYSTEM FOR HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTROMER COMPOSITIONS | Dow Global Technologies Inc. (US) | 2008-08-27 | — | — | EP | claimed |
| WO-2008027757-A1 | A CURE SYSTEM FOR HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTROMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2008-03-06 | — | — | WO | claimed |
| WO-2008027754-A2 | A CURE SYSTEM FOR HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTOMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES INC. (US) | 2008-03-06 | — | — | WO | claimed |
| CN-103827246-B | Adhesive composition, adhesive layer, adhesive sheet, surface protection sheet, optical surface protection sheet, and optical film with surface protection sheet | 日东电工株式会社 | 2018-06-01 | — | — | CN | disclosed |
| EP-2059557-B1 | A CURE SYSTEM FOR HALOGENATED ELASTOMER COMPOSITIONS, A CURABLE HALOGENATED ELASTOMER COMPOSITION, AND A METHOD FOR CURING HALOGENATED ELASTOMER COMPOSITIONS | DOW GLOBAL TECHNOLOGIES LLC (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-2826816-A1 | A curable halogenated elastomer composition and a method for curing halogenated elastomer compositions | Dow Global Technologies LLC (US) | 2015-01-21 | — | — | EP | disclosed |
| US-8252870-B2 | Cure system of halogenated elastomer compositions, a curable halogenated elastomer composition, and a method for curing halogenated elastomer compositions | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-08-28 | — | — | US | disclosed |
| US-20080255313-A1 | Cure System for Chlorinated Elastomer Compositions and a Method of Curing Chlorinated Elastomer Compositions | LAAKSO RAYMOND L | 2008-10-16 | — | — | US | disclosed |
| EP-1861460-A2 | VULCANIZABLE CHLORINATED ELASTOMER COMPOSITIONS WITH IMPROVED PROCESSING SAFETY AND CURE RATE | Dow Gloval Technologies Inc. (US) | 2007-12-05 | — | — | EP | disclosed |
| WO-2007044061-A2 | VULCANIZABLE CHLORINATED ELASTOMER COMPOSITIONS WITH IMPROVED PROCESSING SAFETY AND CURE RATE | DOW GLOBAL TECHNOLOGIES INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| US-20060205889-A1 | cure system composition consisting of a crosslinking agent 2-mercapto-1,3,4-thiadiazole-5-thiobenzoate and accelerators 1-butyl-3-methylimidazolinium chloride; for curing chlorinated polyethylene | DOW GLOBAL TECHNOLOGIES INC. (US) | 2006-09-14 | — | — | US | disclosed |