Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20088593 | 0.93 | ADORA2A (0.42) | ADORA2ATRPA1RPS6KB1ROCK1RPS6KA1 | |
| SCHEMBL20088558 | 0.90 | TRPA1 (0.50) | ADORA2ATRPA1RXRARXRBRXRG | |
| SCHEMBL20094365 | 0.88 | ADORA2A (0.39) | ADORA2ATRPA1RPS6KB1ROCK1RPS6KA1 | |
| SCHEMBL20088604 | 0.88 | ADORA2A (0.40) | ADORA2ATRPA1RPS6KB1ROCK1RPS6KA1 | |
| SCHEMBL20094280 | 0.87 | ADORA2A (0.39) | ADORA2ATRPA1MAPTTRPM8 | |
| SCHEMBL20088570 | 0.86 | ADORA2A (0.40) | ADORA2ATRPA1NOS1RXRARXRB | |
| SCHEMBL20088574 | 0.85 | ADORA2A (0.46) | ADORA2ATRPA1NOS1MAPT | |
| SCHEMBL20088566 | 0.84 | ADORA2A (0.39) | ADORA2ATRPA1RPS6KB1ROCK1RPS6KA1 | |
| SCHEMBL20088564 | 0.84 | ADORA2A (0.39) | ADORA2ATRPA1RPS6KB1ROCK1RPS6KA1 | |
| SCHEMBL20094527 | 0.83 | ADORA2A (0.40) | ADORA2ATRPA1RPS6KB1ROCK1RPS6KA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180111933-A1 | FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111933-A1 | FUSED BICYLIC PYRIDINE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | GRIN1, GRIN3A, GRM1 | ADORA2A 186/4885TRPA1 593/4885RPS6KB1 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.