Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 8/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | BTK | Q06187 | 4/20 | 0.43 |
| ▸ | ITK | Q08881 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857600 | 0.79 | TNIK (0.48) | TNIKPIK3CABTKITKCLK1 | |
| SCHEMBL414901 | 0.76 | KIT (0.50) | TNIKPIK3CABTKITKCYP3A4 | |
| SCHEMBL415724 | 0.75 | TNIK (0.51) | TNIKPIK3CABTKITKCYP3A4 | |
| SCHEMBL15557175 | 0.75 | PIK3CA (0.61) | TNIKPIK3CABTKITKCYP3A4 | |
| SCHEMBL4301666 | 0.74 | PIK3CA (0.51) | TNIKPIK3CABTKITKCLK1 | |
| SCHEMBL4746500 | 0.72 | TNIK (0.58) | TNIKPIK3CACYP3A4CLK1DYRK1A | |
| SCHEMBL3807981 | 0.71 | SGK1 (0.67) | TNIKPIK3CACLK1DYRK1ADYRK2 | |
| SCHEMBL12763541 | 0.71 | KIT (0.64) | TNIKPIK3CAMAP4K1CLK1DYRK1A | |
| SCHEMBL3771136 | 0.71 | TNIK (0.64) | TNIKPIK3CACLK1DYRK1ADYRK2 | |
| SCHEMBL878650 | 0.70 | TNIK (0.54) | TNIKPIK3CABTKITKCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180111929-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2018-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111929-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | TNIK 313/4885PIK3CA 79/4885BTK 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.