Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 11/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4745695 | 0.87 | DYRK1B (0.64) | TNIKCLK1DYRK1ADYRK2DYRK1B | |
| SCHEMBL15557175 | 0.83 | PIK3CA (0.61) | TNIKPIK3CACLK1DYRK1ADYRK2 | |
| SCHEMBL4745741 | 0.80 | CHUK (0.58) | TNIKPIK3CADYRK1ANTRK1PRMT5 | |
| SCHEMBL4745720 | 0.77 | PRMT5 (0.52) | TNIKPIK3CADYRK1ANTRK1PRMT5 | |
| SCHEMBL3807981 | 0.77 | SGK1 (0.67) | TNIKPIK3CACLK1DYRK1ADYRK2 | |
| SCHEMBL3765020 | 0.76 | CAMKK2 (0.75) | TNIKPIK3CACLK1DYRK1ADYRK2 | |
| SCHEMBL3771136 | 0.76 | TNIK (0.64) | TNIKPIK3CACLK1DYRK1ADYRK2 | |
| SCHEMBL12763541 | 0.76 | KIT (0.64) | TNIKPIK3CACLK1DYRK1ADYRK2 | |
| SCHEMBL878650 | 0.75 | TNIK (0.54) | TNIKPIK3CACLK1DYRK1ADYRK2 | |
| SCHEMBL15557044 | 0.75 | ALK (0.72) | TNIKPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |