Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.43 |
| ▸ | FASN | P49327 | 5/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009115 | 1.00 | ELANE (0.46) | ELANEGRIN2BFASNGSK3BHPGD | |
| SCHEMBL10298 | 0.86 | F10 (0.41) | GRIN2BFASNALDH1A1F10SMN1; SMN2 | |
| SCHEMBL2009586 | 0.83 | ELANE (0.50) | ELANEGRIN2BFASNHPGDALDH1A1 | |
| SCHEMBL11909934 | 0.80 | NPC1 (0.41) | GRIN2BALDH1A1MAPTTSHRF10 | |
| SCHEMBL5952 | 0.80 | PTGER4 (0.41) | GRIN2BFASNALDH1A1MAPTF10 | |
| SCHEMBL6716 | 0.77 | ATM (0.39) | ELANEFASNALDH1A1F10VNN1 | |
| SCHEMBL11183 | 0.77 | SCD (0.44) | MAPT | |
| SCHEMBL6714 | 0.77 | ATM (0.39) | ELANEFASNALDH1A1F10VNN1 | |
| SCHEMBL13834992 | 0.76 | DPP4 (0.50) | ELANEGRIN2BFASNALDH1A1MAPT | |
| SCHEMBL6065 | 0.75 | HTT (0.45) | ALDH1A1MAPTF10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2503890-A1 | AZABENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011066211-A1 | AZABENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-06-03 | — | — | WO | disclosed |