Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 5/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | NPM1 | P06748 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20073418 | 0.83 | LMNA (0.44) | TYK2MAPTKMT2AALDH1A1TSHR | |
| SCHEMBL20073647 | 0.79 | TYK2 (0.41) | TYK2MAPTKMT2AALDH1A1TSHR | |
| SCHEMBL26121387 | 0.79 | MAPT (0.50) | TYK2MAPTKMT2AALDH1A1TSHR | |
| SCHEMBL26511011 | 0.78 | MEN1 (0.46) | TYK2MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL20073684 | 0.78 | TYK2 (0.40) | TYK2MAPTKMT2AALDH1A1CYP1A2 | |
| SCHEMBL24498535 | 0.77 | MEN1 (0.48) | TYK2MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL26546136 | 0.76 | TSHR (0.40) | TYK2MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL24497504 | 0.76 | TSHR (0.40) | TYK2MAPTKMT2AALDH1A1HPGD | |
| SCHEMBL26544208 | 0.75 | TSHR (0.40) | TYK2MAPTKMT2AALDH1A1CYP1A2 | |
| SCHEMBL26545858 | 0.75 | TSHR (0.40) | TYK2MAPTKMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075937-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2018-04-26 | — | — | WO | disclosed |