Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.35 |
| ▸ | PDE8B | O95263 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20091689 | 0.80 | YTHDC1 (0.40) | YTHDC1CYP2C19CYP1A2TSHR | |
| SCHEMBL20092927 | 0.78 | YTHDC1 (0.37) | YTHDC1CYP2C19CYP1A2TSHR | |
| SCHEMBL565852 | 0.78 | PDE8B (0.44) | PDE8BTLR7TLR8 | |
| SCHEMBL20091956 | 0.76 | NPC1 (0.36) | YTHDC1PDE8BCYP1A2TSHR | |
| SCHEMBL30471120 | 0.76 | NPC1 (0.36) | YTHDC1PDE8BCYP1A2TSHR | |
| SCHEMBL20092254 | 0.75 | YTHDC1 (0.35) | YTHDC1PDE8BCYP2C19CYP1A2TSHR | |
| SCHEMBL20091846 | 0.75 | YTHDC1 (0.35) | YTHDC1CYP2C19CYP1A2TSHR | |
| SCHEMBL2200949 | 0.75 | PDE8B (0.41) | PDE8BTLR7TLR8 | |
| SCHEMBL20155890 | 0.72 | CD274 (0.30) | — | |
| SCHEMBL20156146 | 0.71 | TYK2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075937-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2018-04-26 | — | — | WO | disclosed |