Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 10/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 9/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 9/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16094553 | 0.92 | MEN1 (0.38) | TP53MEN1KMT2ASCN1ASCN5A | |
| SCHEMBL20238943 | 0.90 | MEN1 (0.36) | MEN1KMT2ASCN1ASCN5ASCN8A | |
| SCHEMBL29668680 | 0.90 | MEN1 (0.36) | MEN1KMT2ASCN1ASCN5ASCN8A | |
| SCHEMBL16771614 | 0.88 | MEN1 (0.38) | TP53MEN1KMT2ASCN1ASCN5A | |
| SCHEMBL29668807 | 0.88 | KDM4E (0.42) | TP53MEN1KMT2ASCN1ASCN9A | |
| SCHEMBL29669070 | 0.88 | MEN1 (0.40) | TP53MEN1KMT2ASCN1ASCN9A | |
| SCHEMBL15466024 | 0.88 | MEN1 (0.40) | TP53MEN1KMT2ASCN1ASCN9A | |
| SCHEMBL20073007 | 0.88 | SCN1A (0.38) | SCN1ASCN5ASCN8ASCN9AKDM4E | |
| SCHEMBL16757120 | 0.87 | MEN1 (0.37) | MEN1KMT2ASCN1ASCN5ASCN8A | |
| SCHEMBL28548900 | 0.86 | SCN9A (0.39) | TP53MEN1KMT2ASCN9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |