Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093593 | 0.92 | SCN9A (0.40) | SCN9ATP53KDM4EPOLBHTR2A | |
| SCHEMBL29736437 | 0.92 | SCN9A (0.40) | SCN9ATP53KDM4EPOLBHTR2A | |
| SCHEMBL21865565 | 0.92 | SCN9A (0.40) | SCN9ATP53KDM4EPOLBGAA | |
| SCHEMBL28912753 | 0.90 | SCN9A (0.39) | SCN9ATP53KDM4EPOLBHTR2A | |
| SCHEMBL20528519 | 0.89 | SCN9A (0.38) | SCN9ATP53KDM4EPOLBHTR2A | |
| SCHEMBL29835251 | 0.88 | SCN9A (0.42) | SCN9ATP53KDM4EPOLBGAA | |
| SCHEMBL1094096 | 0.88 | SCN9A (0.42) | SCN9ATP53KDM4EPOLBGAA | |
| SCHEMBL22035070 | 0.88 | SCN9A (0.39) | SCN9ATP53KDM4EPOLBHTR2A | |
| SCHEMBL28570164 | 0.86 | LMNA (0.40) | SCN9AKDM4EPOLBMEN1KMT2A | |
| SCHEMBL20449359 | 0.86 | SCN9A (0.39) | SCN9ATP53KDM4EPOLBHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112759559-B | Sulfonamide compounds as sodium channel blockers and uses thereof | 成都康弘药业集团股份有限公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-112759559-A | Sulfonamide compounds as sodium channel blockers and uses thereof | 成都康弘药业集团股份有限公司 | 2021-05-07 | — | — | CN | disclosed |