Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 17/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095586 | 1.00 | RIPK1 (0.58) | RIPK1SCN9AXIAP | |
| SCHEMBL20095562 | 0.93 | RIPK1 (0.59) | RIPK1SCN9A | |
| SCHEMBL20095394 | 0.93 | RIPK1 (0.59) | RIPK1SCN9A | |
| SCHEMBL20095567 | 0.81 | RIPK1 (0.53) | RIPK1 | |
| SCHEMBL20095571 | 0.81 | RIPK1 (0.53) | RIPK1 | |
| SCHEMBL23432093 | 0.77 | RIPK1 (0.59) | RIPK1SCN9AXIAP | |
| SCHEMBL20096019 | 0.74 | RIPK1 (0.44) | RIPK1 | |
| SCHEMBL21220867 | 0.74 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL21220677 | 0.74 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL20095890 | 0.72 | RIPK1 (0.55) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018073193-A1 | BICYCLIC PYRIDONE LACTAMS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2018-04-26 | — | — | WO | disclosed |