Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27376990 | 0.97 | DPP4 (0.38) | DPP4SLC18A3ABCB1SIGMAR1HRH3 | |
| SCHEMBL17660856 | 0.91 | HRH3 (0.45) | DPP4SLC18A3ABCB1HRH3PHGDH | |
| SCHEMBL21370058 | 0.84 | DPP4 (0.35) | DPP4SLC18A3ABCB1SIGMAR1HRH3 | |
| SCHEMBL17665810 | 0.84 | SLC18A3 (0.47) | SLC18A3ABCB1HRH3PHGDHMGLL | |
| SCHEMBL1828751 | 0.81 | SLC18A3 (0.43) | SLC18A3ABCB1HRH3PHGDHMGLL | |
| SCHEMBL26514335 | 0.80 | HRH3 (0.44) | ABCB1HRH3 | |
| SCHEMBL1306880 | 0.78 | DPP4 (0.47) | DPP4SLC18A3SIGMAR1PHGDHMGLL | |
| SCHEMBL25189721 | 0.76 | KDM1A (0.36) | DPP4 | |
| SCHEMBL15217755 | 0.76 | ALDH1A1 (0.46) | HRH3 | |
| SCHEMBL15190810 | 0.76 | KDM1A (0.36) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |