Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14934588 | 0.92 | POLB (0.41) | POLBTP53HDAC8GAAMAPK1 | |
| SCHEMBL29481979 | 0.92 | POLB (0.41) | POLBTP53HDAC8GAAMAPK1 | |
| SCHEMBL20095675 | 0.92 | POLB (0.37) | POLBTP53HDAC8GAALMNA | |
| SCHEMBL21312177 | 0.92 | POLB (0.39) | POLBTP53HDAC8GAAMAPK1 | |
| SCHEMBL20095731 | 0.92 | POLB (0.37) | POLBTP53HDAC8GAAMAPK1 | |
| SCHEMBL20073167 | 0.90 | POLB (0.38) | POLBTP53HDAC8GAAMAPK1 | |
| SCHEMBL21904599 | 0.90 | GAA (0.36) | POLBTP53GAAMEN1KMT2A | |
| SCHEMBL20072994 | 0.88 | HRH4 (0.37) | POLBTP53GAAMEN1KMT2A | |
| SCHEMBL15465002 | 0.88 | POLB (0.39) | POLBTP53GAAMAPK1LMNA | |
| SCHEMBL30201222 | 0.88 | POLB (0.39) | POLBTP53GAAMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |