Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | DRD5 | P21918 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20063430 | 0.80 | SCN9A (0.35) | SIGMAR1DRD3SCN9AHTR2AHRH1 | |
| SCHEMBL20072752 | 0.80 | DRD3 (0.35) | SIGMAR1DRD3SCN9AHTR2AHRH1 | |
| SCHEMBL20073061 | 0.80 | DRD3 (0.40) | SIGMAR1DRD3SCN9AHTR2AHRH1 | |
| SCHEMBL20063517 | 0.80 | SCN9A (0.35) | SIGMAR1DRD3SCN9AHTR2AHRH1 | |
| SCHEMBL19402448 | 0.74 | KAT2B (0.50) | SIGMAR1PDPK1HTR2AHTR2CHTR2B | |
| SCHEMBL19402447 | 0.74 | KAT2B (0.50) | SIGMAR1PDPK1HTR2AHTR2CHTR2B | |
| SCHEMBL9772643 | 0.74 | HTR2A (0.41) | SIGMAR1PDPK1HTR2AHTR2CHTR2B | |
| SCHEMBL7969084 | 0.74 | HTR2A (0.41) | SIGMAR1PDPK1HTR2AHTR2CHTR2B | |
| SCHEMBL29236186 | 0.74 | PDPK1 (0.38) | SIGMAR1PDPK1HTR2AHRH1DRD5 | |
| SCHEMBL20073146 | 0.72 | PLAU (0.41) | PDPK1HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |