Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.41 |
| ▸ | HTR2C | P28335 | 12/20 | 0.41 |
| ▸ | HTR2B | P41595 | 12/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9772643 | 1.00 | HTR2A (0.41) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL27203859 | 0.79 | MAPK1 (0.46) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL14076218 | 0.76 | DRD2 (0.50) | HTR2AHTR2CHTR2BHRH3SIGMAR1 | |
| SCHEMBL2578214 | 0.76 | SIGMAR1 (0.45) | HTR2AHTR2CHTR2BSIGMAR1PDPK1 | |
| SCHEMBL12422089 | 0.76 | MAOB (0.46) | HTR2AHTR2CHTR2BSIGMAR1PDPK1 | |
| SCHEMBL15304297 | 0.76 | MAOB (0.46) | HTR2AHTR2CHTR2BSIGMAR1PDPK1 | |
| SCHEMBL12422094 | 0.76 | MAOB (0.46) | HTR2AHTR2CHTR2BSIGMAR1PDPK1 | |
| SCHEMBL12422090 | 0.76 | MAOB (0.46) | HTR2AHTR2CHTR2BSIGMAR1PDPK1 | |
| SCHEMBL15705297 | 0.76 | SIGMAR1 (0.45) | HTR2AHTR2CHTR2BSIGMAR1PDPK1 | |
| SCHEMBL2578228 | 0.76 | SIGMAR1 (0.45) | HTR2AHTR2CHTR2BSIGMAR1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271395-B1 | E.G.,(.+-.)-N-(2,3-DIHYDRO-2-(1-PYRROLIDINYL)-1H-INDEN-1-Y1) -2 ,4-DINITRO-N-METHYL-BENZENE-ACETAMIDE; STRONG AFFINITY FOR OPTICAL RECEPTORS, CENTRAL ANALGESIC, DIURETIC, ANTIARRYTHMIC, HYPOTENSIVE AND ANTIISCHEMIC ACTIVITY. | HOECHST MARION ROUSSOL (FR) | 2001-08-07 | — | — | US | disclosed |
| EP-0258096-B1 | INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE INTERMEDIATES OBTAINED | ROUSSEL-UCLAF (FR) | 1992-09-09 | — | — | EP | disclosed |