Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 8/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 8/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 6/20 | 0.41 |
| ▸ | SCN1A | P35498 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20096031 | 0.82 | SCN5A (0.45) | SCN9ASCN5ASCN8ASCN1ACYP3A4 | |
| SCHEMBL20096055 | 0.81 | SCN5A (0.50) | SCN9ASCN5ASCN8ASCN1ACYP3A4 | |
| SCHEMBL20096167 | 0.80 | SCN9A (0.44) | SCN9ASCN5ASCN8ASCN1ACYP3A4 | |
| SCHEMBL20115559 | 0.80 | SCN5A (0.48) | SCN9ASCN5ASCN8ASCN1ACYP3A4 | |
| SCHEMBL20095918 | 0.79 | SCN5A (0.44) | SCN9ASCN5ASCN8ASCN1ACYP3A4 | |
| SCHEMBL20115723 | 0.77 | SCN5A (0.45) | SCN9ASCN5ASCN8ASCN1ACYP3A4 | |
| SCHEMBL20096222 | 0.76 | SCN9A (0.46) | SCN9ASCN5ASCN8ASCN1ACYP3A4 | |
| SCHEMBL20095953 | 0.76 | SCN9A (0.46) | SCN9ASCN5ASCN8ASCN1ACYP3A4 | |
| SCHEMBL20115554 | 0.73 | SCN5A (0.40) | SCN9ASCN5ASCN8ASCN1ACYP3A4 | |
| SCHEMBL25973048 | 0.72 | SCN9A (0.46) | SCN9ASCN5ASCN8ASCN1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |