Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 8/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 8/20 | 0.39 |
| ▸ | SCN1A | P35498 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20096114 | 0.90 | SCN9A (0.56) | SCN9AHSD11B1SCN5ASCN8ASCN1A | |
| SCHEMBL20063809 | 0.89 | SCN9A (0.59) | SCN9AHSD11B1SCN5ASCN8ASCN1A | |
| SCHEMBL20096207 | 0.78 | SCN9A (0.54) | SCN9AHSD11B1SCN5ASCN8ASCN1A | |
| SCHEMBL19000649 | 0.78 | SCN8A (0.57) | SCN9ASCN5ASCN8ASCN1ANR1I2 | |
| SCHEMBL20095581 | 0.75 | SCN5A (0.59) | SCN9ASCN5ASCN8ASCN1A | |
| SCHEMBL20063614 | 0.73 | SCN9A (1.00) | SCN9A | |
| SCHEMBL20095908 | 0.70 | SCN1A (0.59) | SCN9ASCN5ASCN8ASCN1A | |
| SCHEMBL29668928 | 0.70 | SCN1A (0.59) | SCN9ASCN5ASCN8ASCN1ANR1I2 | |
| SCHEMBL20238319 | 0.70 | SCN1A (0.59) | SCN9ASCN5ASCN8ASCN1ANR1I2 | |
| SCHEMBL20096061 | 0.69 | SCN9A (0.33) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |