Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411071 | 0.82 | TRPV4 (0.35) | TRPV4CYP11B1CYP11B2CHKADAO | |
| SCHEMBL30048138 | 0.82 | TRPV4 (0.35) | TRPV4CYP11B1CYP11B2CHKADAO | |
| SCHEMBL24357673 | 0.79 | KDM1A (0.37) | — | |
| SCHEMBL2651893 | 0.75 | TRPV4 (0.39) | TRPV4ESR1ESR2CYP11B1CYP11B2 | |
| SCHEMBL17316422 | 0.75 | TRPV4 (0.52) | TRPV4 | |
| SCHEMBL240133 | 0.74 | TRPV4 (0.57) | TRPV4CYP11B1CYP11B2DAOMAOB | |
| SCHEMBL51855 | 0.74 | TRPV4 (0.42) | TRPV4CYP11B1CYP11B2CHKADAO | |
| SCHEMBL29413279 | 0.74 | TRPV4 (0.42) | TRPV4CYP11B1CYP11B2CHKADAO | |
| SCHEMBL22802432 | 0.73 | TRPV4 (0.41) | TRPV4 | |
| SCHEMBL22119927 | 0.72 | KHK (0.39) | TRPV4ESR1ESR2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075871-A1 | NOVEL ANTIBIOTICS AND METHODS OF USING SAME | THE BROAD INSTITUTE, INC. (US) | 2018-04-26 | — | — | WO | disclosed |