Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 7/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095685 | 1.00 | HTR2C (0.49) | HTR2CHTR2AHTR2BHRH3CNR2 | |
| SCHEMBL20095682 | 1.00 | HTR2C (0.49) | HTR2CHTR2AHTR2BHRH3CNR2 | |
| SCHEMBL21311629 | 0.87 | HTR1A (0.38) | HTR2CHTR2AHTR2BHRH3CNR2 | |
| SCHEMBL2539686 | 0.82 | HTR2C (0.68) | HTR2CCNR2 | |
| SCHEMBL20095961 | 0.81 | HTR2C (0.54) | HTR2CHTR2AHTR2BHRH3 | |
| SCHEMBL21311815 | 0.81 | SCN9A (0.36) | HTR2CHTR2AHTR2BHRH3 | |
| SCHEMBL20095708 | 0.81 | HTR2C (0.54) | HTR2CHTR2AHTR2BHRH3 | |
| SCHEMBL20095707 | 0.81 | HTR2C (0.54) | HTR2CHTR2AHTR2BHRH3 | |
| SCHEMBL20096265 | 0.81 | HTR2C (0.54) | HTR2CHTR2AHTR2BHRH3 | |
| SCHEMBL20095686 | 0.81 | HTR2C (0.54) | HTR2CHTR2AHTR2BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |