Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 4/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095825 | 1.00 | HTR1A (0.55) | HTR1AHTR7HTR2CSLC6A4BRD4 | |
| SCHEMBL14431404 | 0.83 | SLC6A4 (0.45) | HTR1AHTR7SLC6A4 | |
| SCHEMBL13197437 | 0.83 | HTR2C (0.54) | HTR1AHTR7HTR2CBRD4SOS1 | |
| SCHEMBL14336850 | 0.80 | SLC6A4 (0.53) | HTR1AHTR7HTR2CSLC6A4HTR2A | |
| SCHEMBL5200165 | 0.80 | SLC6A4 (0.45) | HTR1AHTR7SLC6A4 | |
| SCHEMBL20096104 | 0.78 | HTR1A (0.55) | HTR1AHTR7HTR2CSLC6A4BRD4 | |
| SCHEMBL18866771 | 0.78 | HTR2C (0.51) | HTR1AHTR7HTR2CSOS1KDM1A | |
| SCHEMBL9945846 | 0.73 | HTR1A (0.66) | HTR1AHTR7HTR2CKDM1AHTR6 | |
| SCHEMBL20063387 | 0.72 | HTR1A (0.41) | HTR1AHTR7HTR2CKDM1AHTR2A | |
| SCHEMBL9945840 | 0.71 | HTR1A (1.00) | HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |