Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12414833 | 0.86 | JAK2 (0.50) | SMN1; SMN2POLBL3MBTL1NPSR1JAK2 | |
| SCHEMBL12304216 | 0.86 | JAK2 (0.50) | SMN1; SMN2POLBL3MBTL1NPSR1JAK2 | |
| SCHEMBL12414834 | 0.86 | JAK2 (0.50) | SMN1; SMN2POLBL3MBTL1NPSR1JAK2 | |
| SCHEMBL20063333 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBL3MBTL1NPSR1JAK2 | |
| SCHEMBL12764370 | 0.81 | MEN1 (0.49) | SMN1; SMN2POLBL3MBTL1NPSR1JAK2 | |
| SCHEMBL20095899 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBL3MBTL1NPSR1JAK2 | |
| SCHEMBL24974012 | 0.78 | SMN1; SMN2 (0.59) | SMN1; SMN2POLBL3MBTL1NPSR1KMT2A | |
| SCHEMBL19104799 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBL3MBTL1NPSR1HDAC1 | |
| SCHEMBL17190676 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBL3MBTL1NPSR1KMT2A | |
| SCHEMBL15490020 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBL3MBTL1NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |