Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095391 | 0.89 | MEN1 (0.38) | MEN1KMT2AMAPTATRPABPC1 | |
| SCHEMBL29713519 | 0.84 | NNMT (0.47) | MEN1KMT2AATRPABPC1AAK1 | |
| SCHEMBL7681674 | 0.84 | NNMT (0.47) | MEN1KMT2AATRPABPC1AAK1 | |
| SCHEMBL28391719 | 0.83 | NNMT (0.39) | MEN1KMT2AATRPABPC1AAK1 | |
| SCHEMBL12513167 | 0.83 | ATR (0.38) | MEN1KMT2AMAPTATRPABPC1 | |
| SCHEMBL1430094 | 0.83 | ATR (0.38) | MEN1KMT2AATRPABPC1AAK1 | |
| SCHEMBL6217868 | 0.82 | KMT2A (0.40) | MEN1KMT2AMAPTATRPABPC1 | |
| SCHEMBL20770870 | 0.82 | ATR (0.48) | MEN1KMT2AATRPABPC1AAK1 | |
| SCHEMBL29764732 | 0.82 | ATR (0.40) | MEN1KMT2AATRPABPC1AAK1 | |
| SCHEMBL29589580 | 0.82 | KMT2A (0.40) | MEN1KMT2AMAPTATRPABPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843886-B | Bicyclic pyridone lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2022-04-19 | — | — | CN | disclosed |
| EP-3526219-B1 | BICYCLIC PYRIDONE LACTAMS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2021-12-15 | — | — | EP | disclosed |
| WO-2018073193-A1 | BICYCLIC PYRIDONE LACTAMS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2018-04-26 | — | — | WO | disclosed |