Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18367287 | 0.78 | RIPK1 (0.44) | KDM1AKDM1BALDH1A1KMT2ACYP3A4 | |
| SCHEMBL27456585 | 0.70 | KDM1A (0.49) | KDM1AKDM1BSRD5A1P2RX7DGAT1 | |
| SCHEMBL18372940 | 0.70 | USP30 (0.40) | SRD5A1P2RX7DDB1CRBNALDH1A1 | |
| SCHEMBL20268153 | 0.70 | USP30 (0.40) | SRD5A1P2RX7DDB1CRBNALDH1A1 | |
| SCHEMBL31478611 | 0.68 | RIPK1 (0.39) | SRD5A1P2RX7NPSR1KMT2ACYP3A4 | |
| SCHEMBL8243578 | 0.68 | KDM1A (0.58) | KDM1AKDM1BDGAT1ALDH1A1 | |
| SCHEMBL29739167 | 0.68 | KDM1A (0.58) | KDM1AKDM1BDGAT1ALDH1A1 | |
| SCHEMBL22781364 | 0.67 | SRD5A1 (0.42) | SRD5A1P2RX7DDB1CRBN | |
| SCHEMBL22781413 | 0.67 | SRD5A1 (0.55) | SRD5A1P2RX7NPSR1KMT2ACYP3A4 | |
| SCHEMBL22778088 | 0.66 | KDM1A (0.56) | KDM1AKDM1BDGAT1NPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018073193-A1 | BICYCLIC PYRIDONE LACTAMS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2018-04-26 | — | — | WO | disclosed |