Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20096261 | 1.00 | SCN9A (0.42) | SCN9ADRD2DRD3TAS1R3TAS1R1 | |
| SCHEMBL21311996 | 0.84 | SCN9A (0.38) | SCN9ADRD2DRD3DRD1HCRTR2 | |
| SCHEMBL25046792 | 0.81 | HTR2C (0.45) | DRD2DRD3TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL21311697 | 0.81 | HTR2C (0.38) | SCN9ADRD2DRD3MGLLHTR2C | |
| SCHEMBL21311899 | 0.81 | PIM1 (0.38) | DRD2DRD3TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL20096265 | 0.81 | HTR2C (0.54) | SCN9ADRD2HTR2C | |
| SCHEMBL20095961 | 0.81 | HTR2C (0.54) | SCN9ADRD2HTR2C | |
| SCHEMBL20095708 | 0.81 | HTR2C (0.54) | SCN9ADRD2HTR2C | |
| SCHEMBL20095707 | 0.81 | HTR2C (0.54) | SCN9ADRD2HTR2C | |
| SCHEMBL20095686 | 0.81 | HTR2C (0.54) | SCN9ADRD2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |