Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095849 | 0.82 | MGLL (0.42) | HTR2CSLC6A4MGLL | |
| SCHEMBL20095848 | 0.82 | MGLL (0.42) | HTR2CSLC6A4MGLL | |
| SCHEMBL20096106 | 0.82 | MGLL (0.42) | HTR2CSLC6A4MGLL | |
| SCHEMBL20096261 | 0.81 | SCN9A (0.42) | HTR2CDRD2SCN9ADRD3MGLL | |
| SCHEMBL21311996 | 0.81 | SCN9A (0.38) | HTR2CDRD2SCN9ADRD3ALOX5 | |
| SCHEMBL20096086 | 0.81 | SCN9A (0.42) | HTR2CDRD2SCN9ADRD3MGLL | |
| SCHEMBL21311808 | 0.78 | HTR2C (0.50) | HTR2CDRD2SLC6A4SLC6A3DRD3 | |
| SCHEMBL21311628 | 0.78 | HTR2C (0.50) | HTR2CDRD2SLC6A4SLC6A3DRD3 | |
| SCHEMBL20095514 | 0.77 | HTR2A (0.50) | HTR2CSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL21312221 | 0.77 | MGLL (0.39) | HTR2CSLC6A4SCN9AMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165290-A1 | PYRIDINE-SULFONAMIDE COMPOUNDS AND THEIR USE AGAINST PAIN AND RELATED CONDITIONS | GENENTECH, INC. (US) | 2019-08-29 | — | — | WO | disclosed |