Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
| ▸ | SSTR3 | P32745 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | FABP6 | P51161 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26620794 | 1.00 | KDM1A (0.50) | KDM1AMAOAFUCA1GRIN2BHTT | |
| SCHEMBL2197651 | 0.91 | KDM1A (0.58) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| SCHEMBL2936924 | 0.91 | KDM1A (0.58) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| SCHEMBL2798417 | 0.91 | KDM1A (0.58) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| SCHEMBL2198525 | 0.91 | KDM1A (0.58) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| SCHEMBL491107 | 0.91 | KDM1A (0.58) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| SCHEMBL2197644 | 0.91 | KDM1A (0.58) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| Ammonia Solution, Strong SCHEMBL2987109 | 0.89 | KDM1A (0.56) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| Bromide SCHEMBL17822672 | 0.89 | KDM1A (0.56) | KDM1AMAOAFUCA1GRIN2BSSTR3 | |
| Bromide SCHEMBL17822680 | 0.89 | KDM1A (0.56) | KDM1AMAOAFUCA1GRIN2BSSTR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |