Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | CASR | P41180 | 2/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | PHGDH | O43175 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20095964 | 1.00 | NOTUM (0.54) | NOTUMPOLBALDH1A1CASRHTR3E | |
| SCHEMBL17754046 | 0.83 | ALDH1A1 (0.59) | NOTUMPOLBALDH1A1HTR3EHTR3B | |
| SCHEMBL9310553 | 0.81 | IDH2 (0.59) | NOTUMPOLBALDH1A1CASRHTR3E | |
| SCHEMBL19314077 | 0.80 | NOTUM (0.53) | NOTUMPOLBALDH1A1CASRHTR3E | |
| Hydrochloric Acid SCHEMBL9876646 | 0.80 | IDH2 (0.58) | NOTUMPOLBALDH1A1CASRHTR3E | |
| SCHEMBL31058047 | 0.79 | MCHR1 (0.48) | NOTUMHTR1DHTR3AFPR1FPR2 | |
| SCHEMBL27613690 | 0.79 | MCHR1 (0.48) | NOTUMHTR1DHTR3AFPR1FPR2 | |
| Hydrochloric Acid SCHEMBL27858924 | 0.78 | MCHR1 (0.47) | NOTUMHTR1DHTR3AFPR1FPR2 | |
| SCHEMBL11544167 | 0.78 | NOTUM (0.57) | NOTUMPOLBALDH1A1CASRHTR3E | |
| SCHEMBL20063904 | 0.78 | NOTUM (0.57) | NOTUMPOLBALDH1A1CASRHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018072602-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-04-26 | — | — | WO | disclosed |