Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 8/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20096695 | 0.93 | KIF11 (0.35) | KIF11HDAC11ITKCYP2C9ADORA2A | |
| SCHEMBL20132833 | 0.86 | KIF11 (0.46) | KIF11HDAC11ITKCYP2C9ADORA2A | |
| SCHEMBL20096698 | 0.86 | KIF11 (0.46) | KIF11HDAC11ITKCYP2C9ADORA2A | |
| SCHEMBL20096428 | 0.85 | HDAC11 (0.51) | KIF11HDAC11ITKCYP2C9ADORA2A | |
| SCHEMBL20096655 | 0.82 | KIF11 (0.46) | KIF11HDAC11ITKCYP2C9ADORA2A | |
| SCHEMBL29624666 | 0.82 | HDAC11 (0.53) | KIF11HDAC11ITKCYP2C9ADORA2A | |
| SCHEMBL20096430 | 0.82 | HDAC11 (0.53) | KIF11HDAC11ITKCYP2C9ADORA2A | |
| SCHEMBL20096640 | 0.74 | MC4R (0.41) | CYP2C9ADORA2AAR | |
| SCHEMBL20096421 | 0.73 | HDAC11 (0.51) | KIF11HDAC11EGFRRAF1BRAF | |
| SCHEMBL20096646 | 0.73 | MC4R (0.43) | HDAC11CYP2C9ADORA2AAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018075959-A1 | METHODS USING HDAC11 INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2018-04-26 | — | — | WO | disclosed |