Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 5/20 | 0.80 |
| ▸ | DNMT3B | Q9UBC3 | 3/20 | 0.80 |
| ▸ | PNMT | P11086 | 2/20 | 0.80 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.80 |
| ▸ | AHCY | P23526 | 6/20 | 0.78 |
| ▸ | NADK | O95544 | 1/20 | 0.78 |
| ▸ | PRMT7 | Q9NVM4 | 2/20 | 0.77 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.71 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.71 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.71 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.71 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.71 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.71 |
| ▸ | INMT | O95050 | 1/20 | 0.71 |
| ▸ | NSD2 | O96028 | 1/20 | 0.71 |
| ▸ | NNMT | P40261 | 1/20 | 0.71 |
| ▸ | HNMT | P50135 | 1/20 | 0.71 |
| ▸ | WDR5 | P61964 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21311416 | 0.94 | DOT1L (0.72) | DOT1LDNMT3BPNMTDNMT1AHCY | |
| SCHEMBL20096996 | 0.90 | DOT1L (0.69) | DOT1LDNMT3BPNMTDNMT1AHCY | |
| SCHEMBL14174635 | 0.89 | DOT1L (1.00) | DOT1LDNMT3BPNMTDNMT1AHCY | |
| SCHEMBL1490900 | 0.89 | DOT1L (0.84) | DOT1LDNMT3BPNMTDNMT1AHCY | |
| SCHEMBL6902227 | 0.89 | DOT1L (0.84) | DOT1LDNMT3BPNMTDNMT1AHCY | |
| SCHEMBL1490901 | 0.89 | DOT1L (0.84) | DOT1LDNMT3BPNMTDNMT1AHCY | |
| SCHEMBL8572440 | 0.89 | DOT1L (1.00) | DOT1LDNMT3BPNMTDNMT1AHCY | |
| SCHEMBL16272276 | 0.89 | DOT1L (1.00) | DOT1LDNMT3BPNMTDNMT1AHCY | |
| SCHEMBL5055464 | 0.89 | DOT1L (1.00) | DOT1LDNMT3BPNMTDNMT1AHCY | |
| SCHEMBL21243035 | 0.89 | DOT1L (0.84) | DOT1LDNMT3BPNMTDNMT1AHCY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190262371-A1 | METHODS AND COMPOSITION FOR THE TREATMENT OF RNA VIRAL INFECTIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-08-29 | — | — | US | disclosed |
| WO-2018075947-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF RNA VIRAL INFECTIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190262371-A1 | METHODS AND COMPOSITION FOR THE TREATMENT OF RNA VIRAL INFECTIONS | POLRMT, EIF2AK2, NSUN3 | DOT1L 2274/4885DNMT3B 465/4885PNMT 2859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.