Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2778126 | 0.84 | CYP19A1 (0.32) | CYP19A1 | |
| Hydrochloric Acid SCHEMBL12541637 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL7524396 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL4241154 | 0.76 | CYP19A1 (0.34) | CYP19A1 | |
| Hydrochloric Acid SCHEMBL6662492 | 0.75 | — | — | |
| SCHEMBL945379 | 0.70 | NPC1 (0.36) | CYP19A1 | |
| Hydrochloric Acid SCHEMBL2352112 | 0.70 | CYP19A1 (0.32) | CYP19A1 | |
| SCHEMBL12473619 | 0.69 | NPC1 (0.32) | CYP19A1 | |
| Hydrochloric Acid SCHEMBL5582101 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL7772210 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9115229-B2 | Particulate metallocene-alumoxane catalyst | TOTAL RESEARCH & TECHNOLOGY FELUY (BE) | 2015-08-25 | — | — | US | claimed |
| US-20140213743-A1 | Particulate Metallocene-Alumoxane Catalyst | TOTAL RESEARCH & TECHNOLOGY FELUY (BE) | 2014-07-31 | — | — | US | claimed |
| US-8722567-B2 | Particulate metallocene-alumoxane catalyst | TOTAL RESEARCH & TECHNOLOGY FELUY (BE) | 2014-05-13 | — | — | US | claimed |
| US-20140045681-A1 | Particulate Metallocene-Alumoxane Catalyst | TOTAL RESEARCH & TECHNOLOGY FELUY (BE) | 2014-02-13 | — | — | US | claimed |
| US-8445607-B2 | Process for the preparation of a particulate bimodal polyethylene product | TOTAL RESEARCH & TECHNOLOGY FELUY (BE) | 2013-05-21 | — | — | US | claimed |
| US-20120245307-A1 | PROCESS FOR THE PREPARATION OF A PARTICULATE BIMODAL POLYETHYLENE PRODUCT | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2012-09-27 | — | — | US | claimed |
| WO-2011073364-A1 | PROCESS FOR THE PREPARATION OF A PARTICULATE BIMODAL POLYETHYLENE PRODUCT | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2011-06-23 | — | — | WO | claimed |
| US-9115229-B2 | Particulate metallocene-alumoxane catalyst | TOTAL RESEARCH & TECHNOLOGY FELUY (BE) | 2015-08-25 | — | — | US | disclosed |
| US-9085650-B2 | Method for replacing incompatible ethylene polymerization catalysts | TOTAL RESEARCH & TECHNOLOGY FELUY (BE) | 2015-07-21 | — | — | US | disclosed |
| US-8722567-B2 | Particulate metallocene-alumoxane catalyst | TOTAL RESEARCH & TECHNOLOGY FELUY (BE) | 2014-05-13 | — | — | US | disclosed |
| US-8552125-B2 | Process for the preparation of a particulate polyethylene product | TOTAL RESEARCH & TECHNOLOGY FELUY (BE) | 2013-10-08 | — | — | US | disclosed |
| US-8445607-B2 | Process for the preparation of a particulate bimodal polyethylene product | TOTAL RESEARCH & TECHNOLOGY FELUY (BE) | 2013-05-21 | — | — | US | disclosed |
| US-20120271011-A1 | PROCESS FOR THE PREPARATION OF A PARTICULATE POLYETHYLENE PRODUCT | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2012-10-25 | — | — | US | disclosed |
| US-20120245307-A1 | PROCESS FOR THE PREPARATION OF A PARTICULATE BIMODAL POLYETHYLENE PRODUCT | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2012-09-27 | — | — | US | disclosed |
| EP-2382248-A1 | PROCESS FOR PREPARING A BIMODAL POLYETHYLENE PRODUCT IN A SINGLE LOOP REACTOR | Total Petrochemicals Research Feluy (BE) | 2011-11-02 | — | — | EP | disclosed |
| WO-2011073365-A1 | PROCESS FOR PREPARING A BIMODAL POLYETHYLENE PRODUCT IN A SINGLE LOOP REACTOR | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073364-A1 | PROCESS FOR THE PREPARATION OF A PARTICULATE BIMODAL POLYETHYLENE PRODUCT | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073379-A1 | PROCESS FOR THE PREPARATION OF A PARTICULATE POLYETHYLENE PRODUCT | TOTAL PETROCHEMICALS RESEARCH FELUY (BE) | 2011-06-23 | — | — | WO | disclosed |