Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368788 | 0.82 | TAAR1 (0.64) | TAAR1MAPK1CYP2C19KIF11HIF1A | |
| SCHEMBL21413937 | 0.81 | CHRM2 (0.49) | TAAR1KDM4ECHRM2CHRM3CYP3A4 | |
| SCHEMBL19670976 | 0.79 | TAAR1 (0.50) | TAAR1MAPK1CYP11B1CYP11B2CYP2C19 | |
| SCHEMBL19156001 | 0.78 | TAAR1 (0.41) | TAAR1MAPK1CYP11B1CYP11B2KCNA5 | |
| SCHEMBL24235964 | 0.77 | CYP19A1 (0.34) | — | |
| SCHEMBL21755768 | 0.76 | TAAR1 (0.56) | TAAR1MAPK1CYP2C19KIF11HIF1A | |
| SCHEMBL2749938 | 0.76 | CYP1A2 (0.53) | TAAR1CYP2C19CYP3A4 | |
| SCHEMBL19261366 | 0.74 | TLR8 (0.31) | — | |
| SCHEMBL2696931 | 0.74 | ALDH1A1 (0.46) | TAAR1KDM4ECHRM2MAPK1CYP2C19 | |
| Hydrochloric Acid SCHEMBL29145905 | 0.72 | TAAR1 (0.52) | TAAR1MAPK1CYP11B1CYP11B2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9957283-B1 | Processes for making alkylated arylpiperazine and alkylated arylpiperidine compounds including novel intermediates | JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) | 2018-05-01 | — | — | US | disclosed |