Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22965525 | 1.00 | HPGD (0.50) | HPGDDUSP3ALDH1A1KEAP1SMN1; SMN2 | |
| SCHEMBL4312012 | 0.85 | HPGD (0.53) | HPGDDUSP3ALDH1A1KEAP1SMN1; SMN2 | |
| SCHEMBL18596081 | 0.83 | HPGD (0.51) | HPGDDUSP3ALDH1A1KEAP1SMN1; SMN2 | |
| SCHEMBL11432858 | 0.82 | HPGD (0.54) | HPGDDUSP3ALDH1A1KEAP1SMN1; SMN2 | |
| SCHEMBL22651218 | 0.81 | ALDH1A1 (0.55) | HPGDDUSP3ALDH1A1KEAP1SMN1; SMN2 | |
| SCHEMBL19226639 | 0.81 | HPGD (0.49) | HPGDDUSP3ALDH1A1KEAP1SMN1; SMN2 | |
| SCHEMBL16589287 | 0.80 | HPGD (0.47) | HPGDDUSP3ALDH1A1KEAP1SMN1; SMN2 | |
| SCHEMBL14025156 | 0.79 | PAOX (0.49) | HPGDDUSP3ALDH1A1KEAP1SMN1; SMN2 | |
| SCHEMBL25788470 | 0.78 | HPGD (0.46) | HPGDDUSP3ALDH1A1KEAP1SMN1; SMN2 | |
| SCHEMBL24578068 | 0.78 | HPGD (0.53) | HPGDDUSP3ALDH1A1KEAP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9957290-B2 | Derivatives of amphotericin B | SFUNGA THERAPEUTICS, INC. (US) | 2018-05-01 | — | — | US | disclosed |