Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 5/20 | 0.59 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.59 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.55 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.55 |
| ▸ | MC3R | P41968 | 9/20 | 0.55 |
| ▸ | MC4R | P32245 | 8/20 | 0.55 |
| ▸ | MC5R | P33032 | 8/20 | 0.55 |
| ▸ | MC1R | Q01726 | 8/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20104588 | 0.96 | PCSK9 (0.62) | KLKB1PCSK9PDCD1CD274MC3R | |
| SCHEMBL20104581 | 0.90 | PCSK9 (0.62) | KLKB1PCSK9PDCD1CD274MC3R | |
| SCHEMBL29666534 | 0.90 | HDAC3 (0.61) | PCSK9CD274HDAC3HDAC4HDAC1 | |
| SCHEMBL23835709 | 0.89 | MC4R (0.60) | KLKB1PCSK9PDCD1CD274MC3R | |
| SCHEMBL20100614 | 0.87 | MC4R (0.57) | KLKB1PCSK9PDCD1CD274MC3R | |
| SCHEMBL20104643 | 0.87 | PCSK9 (0.59) | KLKB1PCSK9PDCD1CD274MC3R | |
| SCHEMBL29666814 | 0.86 | ACE2 (0.56) | KLKB1PCSK9PDCD1CD274HDAC3 | |
| SCHEMBL29666558 | 0.86 | HDAC3 (0.64) | MC3RMC5RHDAC3HDAC4HDAC1 | |
| SCHEMBL20104593 | 0.86 | PCSK9 (0.58) | KLKB1PCSK9PDCD1CD274MC3R | |
| SCHEMBL20104592 | 0.86 | PCSK9 (0.58) | KLKB1PCSK9PDCD1CD274MC3R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118789-A1 | CHIMERIC MELANOCORTIN LIGANDS AND METHODS OF USE THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118789-A1 | CHIMERIC MELANOCORTIN LIGANDS AND METHODS OF USE THEREOF | MC3R, MC4R, MC1R | KLKB1 2392/4885PCSK9 2460/4885PDCD1 3722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.