Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.59 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.55 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.54 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.54 |
| ▸ | MC4R | P32245 | 9/20 | 0.54 |
| ▸ | MC1R | Q01726 | 9/20 | 0.54 |
| ▸ | MC5R | P33032 | 8/20 | 0.54 |
| ▸ | MC3R | P41968 | 7/20 | 0.54 |
| ▸ | F12 | P00748 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20104592 | 0.99 | PCSK9 (0.58) | PCSK9KLKB1PDCD1CD274MC4R | |
| SCHEMBL20104593 | 0.99 | PCSK9 (0.58) | PCSK9KLKB1PDCD1CD274MC4R | |
| SCHEMBL20104589 | 0.94 | MC1R (0.53) | PCSK9KLKB1MC4RMC1RMC5R | |
| SCHEMBL20104572 | 0.94 | PCSK9 (0.52) | PCSK9KLKB1MC4RMC1RMC5R | |
| SCHEMBL20104573 | 0.93 | TUBB4A (0.52) | PCSK9KLKB1MC4RMC1RMC5R | |
| SCHEMBL20104581 | 0.90 | PCSK9 (0.62) | PCSK9KLKB1PDCD1CD274MC4R | |
| SCHEMBL20104588 | 0.89 | PCSK9 (0.62) | PCSK9KLKB1PDCD1CD274MC4R | |
| SCHEMBL20100616 | 0.87 | KLKB1 (0.59) | PCSK9KLKB1PDCD1CD274MC4R | |
| SCHEMBL20104590 | 0.84 | SSTR1 (0.58) | PCSK9KLKB1MC4RMC1RMC5R | |
| SCHEMBL20104642 | 0.84 | MC4R (0.59) | PCSK9KLKB1PDCD1CD274MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11124541-B2 | Chimeric melanocortin ligands and methods of use thereof | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2021-09-21 | — | — | US | disclosed |
| US-20180118789-A1 | CHIMERIC MELANOCORTIN LIGANDS AND METHODS OF USE THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11124541-B2 | Chimeric melanocortin ligands and methods of use thereof | MC3R, MC4R, MC1R | PCSK9 2460/4885KLKB1 2392/4885PDCD1 3722/4885 |
| US-20180118789-A1 | CHIMERIC MELANOCORTIN LIGANDS AND METHODS OF USE THEREOF | MC3R, MC4R, MC1R | PCSK9 2460/4885KLKB1 2392/4885PDCD1 3722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.