Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.68 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | STS | P08842 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17941243 | 1.00 | PTPN2 (0.68) | PTPN2PTPN1POLBSMN1; SMN2MAPT | |
| SCHEMBL13169514 | 1.00 | PTPN2 (0.68) | PTPN2PTPN1POLBSMN1; SMN2MAPT | |
| SCHEMBL27400395 | 0.98 | PTPN2 (0.70) | PTPN2PTPN1POLBSMN1; SMN2MAPT | |
| SCHEMBL18460807 | 0.95 | PTPN2 (0.70) | PTPN2PTPN1POLBSMN1; SMN2MAPT | |
| SCHEMBL24516605 | 0.85 | POLB (0.65) | PTPN2PTPN1POLBSMN1; SMN2MAPT | |
| SCHEMBL15611198 | 0.85 | PTPN2 (0.65) | PTPN2PTPN1POLBSMN1; SMN2MAPT | |
| SCHEMBL1063538 | 0.85 | PTPN2 (0.65) | PTPN2PTPN1POLBSMN1; SMN2MAPT | |
| SCHEMBL1063540 | 0.85 | PTPN2 (0.65) | PTPN2PTPN1POLBSMN1; SMN2MAPT | |
| SCHEMBL110657 | 0.85 | SMN1; SMN2 (0.68) | PTPN2PTPN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL23015486 | 0.84 | POLB (0.67) | PTPN2PTPN1POLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180116993-A1 | MODULATORS OF FARNESOID X RECEPTOR AND METHODS FOR THE USE THEREOF | XIAMEN UNIVERSITY (CN) | 2018-05-03 | — | — | US | disclosed |
| US-20180116993-A1 | MODULATORS OF FARNESOID X RECEPTOR AND METHODS FOR THE USE THEREOF | XIAMEN UNIVERSITY (CN) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180116993-A1 | MODULATORS OF FARNESOID X RECEPTOR AND METHODS FOR THE USE THEREOF | NR1H4, FABP1, NR1H2 | PTPN2 1112/4885PTPN1 1250/4885POLB 4329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.