Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17941239 | 0.91 | POLB (0.60) | POLBPTPN2PTPN1CHRM2CHRM4 | |
| SCHEMBL8140569 | 0.90 | PTPN2 (0.68) | POLBPTPN2PTPN1CHRM2CHRM4 | |
| SCHEMBL18460807 | 0.88 | PTPN2 (0.70) | POLBPTPN2PTPN1CHRM2CHRM4 | |
| SCHEMBL29582017 | 0.86 | PTPN2 (0.68) | POLBPTPN2PTPN1CHRM2CHRM4 | |
| SCHEMBL27400395 | 0.85 | PTPN2 (0.70) | POLBPTPN2PTPN1CHRM2CHRM4 | |
| SCHEMBL3977630 | 0.84 | POLB (0.90) | POLBPTPN2PTPN1CHRM2CHRM4 | |
| SCHEMBL3977633 | 0.84 | POLB (0.90) | POLBPTPN2PTPN1CHRM2CHRM4 | |
| SCHEMBL20100945 | 0.84 | PTPN2 (0.68) | POLBPTPN2PTPN1CHRM2CHRM4 | |
| SCHEMBL17941243 | 0.84 | PTPN2 (0.68) | POLBPTPN2PTPN1CHRM2CHRM4 | |
| SCHEMBL13169514 | 0.84 | PTPN2 (0.68) | POLBPTPN2PTPN1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10927105-B1 | Pyrazole MAGL inhibitors | LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) | 2021-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927105-B1 | Pyrazole MAGL inhibitors | MGLL, PNLIP, LPL | POLB 2307/4885PTPN2 2403/4885PTPN1 1858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.