Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.56 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6715790 | 0.84 | PAX8 (0.67) | KMT2ASMN1; SMN2OPRK1MAPTHSP90AA1 | |
| SCHEMBL6715793 | 0.84 | PAX8 (0.67) | KMT2ASMN1; SMN2OPRK1MAPTHSP90AA1 | |
| SCHEMBL20101085 | 0.84 | PAX8 (0.67) | KMT2ASMN1; SMN2OPRK1MAPTHSP90AA1 | |
| SCHEMBL31237795 | 0.81 | KDM4E (0.68) | KMT2ASMN1; SMN2OPRK1MAPTHSP90AA1 | |
| SCHEMBL21467818 | 0.78 | MAPT (1.00) | KMT2ASMN1; SMN2OPRK1MAPTHSP90AA1 | |
| SCHEMBL20101020 | 0.77 | PAX8 (0.59) | KMT2ASMN1; SMN2OPRK1MAPTHSP90AA1 | |
| SCHEMBL11483728 | 0.75 | GRM4 (0.63) | SMN1; SMN2MAPTNPSR1RAB9ANPC1 | |
| SCHEMBL14540616 | 0.74 | KMT2A (0.75) | KMT2ASMN1; SMN2OPRK1MAPTHSP90AA1 | |
| SCHEMBL28153216 | 0.74 | KMT2A (0.75) | KMT2ASMN1; SMN2OPRK1MAPTHSP90AA1 | |
| SCHEMBL10289446 | 0.74 | KDM4E (0.52) | KMT2ASMN1; SMN2MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081612-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER | ACTAVALON, INC. (US) | 2018-05-03 | — | — | WO | disclosed |