Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.72 |
| ▸ | MAOB | P27338 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28366328 | 1.00 | MAOA (0.72) | MAOAMAOBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28720595 | 0.92 | MAOA (0.61) | MAOAMAOBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28720593 | 0.92 | MAOA (0.61) | MAOAMAOBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28719673 | 0.89 | MAOA (0.61) | MAOAMAOBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28362720 | 0.89 | MAOA (0.58) | MAOAMAOBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28362719 | 0.89 | MAOA (0.58) | MAOAMAOBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28719677 | 0.89 | MAOA (0.61) | MAOAMAOBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28362601 | 0.84 | MAOA (0.63) | MAOAMAOBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28362727 | 0.84 | MAOA (0.63) | MAOAMAOBMEN1KMT2AGAA | |
| SCHEMBL28723609 | 0.84 | MAOA (0.63) | MAOAMAOBALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110713487-B | Novel heterocyclic aromatic hydrazone derivative, pharmaceutically acceptable salt thereof, preparation method and application thereof | 南京大学 | 2022-02-15 | — | — | CN | disclosed |
| CN-110713487-A | Novel heterocyclic aromatic hydrazone derivative, pharmaceutically acceptable salt thereof, preparation method and application thereof | 南京大学 | 2020-01-21 | — | — | CN | disclosed |
| WO-2018081612-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER | ACTAVALON, INC. (US) | 2018-05-03 | — | — | WO | disclosed |