SCHEMBL20101035

SCHEMBL20101035

C/C(=N\Nc1nc2cc(C(F)(F)F)ccc2s1)c1ccccn1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.54
DYRK1A Q13627 2/20 0.54
MAOA P21397 2/20 0.53
MAOB P27338 2/20 0.53
ALDH1A1 P00352 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
HIF1A Q16665 1/20 0.50
PAX8 Q06710 2/20 0.47
NCS1 P62166 1/20 0.47
KMT2A Q03164 4/20 0.44
NPC1 O15118 3/20 0.44
MEN1 O00255 3/20 0.44
GAA P10253 3/20 0.44
RAB9A P51151 2/20 0.44
LMNA P02545 1/20 0.44
HPGD P15428 1/20 0.44
ALOX12 P18054 1/20 0.44
MAPT P10636 2/20 0.43
NPSR1 Q6W5P4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20101027 0.87 DYRK1A (0.48) HSP90AA1DYRK1AMAOAMAOBALDH1A1
SCHEMBL17963013 0.86 HSP90AA1 (0.57) HSP90AA1DYRK1AMAOAMAOBALDH1A1
SCHEMBL20101038 0.85 HSP90AA1 (0.71) HSP90AA1DYRK1AMAOAMAOBALDH1A1
SCHEMBL17985747 0.83 HSP90AA1 (0.76) HSP90AA1MAOAMAOBALDH1A1CYP1A2
SCHEMBL17987878 0.82 HSP90AA1 (0.55) HSP90AA1DYRK1AMAOAMAOBALDH1A1
SCHEMBL17987886 0.81 HSP90AA1 (0.54) HSP90AA1DYRK1AMAOAMAOBALDH1A1
SCHEMBL17985741 0.79 RAB9A (0.65) HSP90AA1DYRK1AMAOAMAOBALDH1A1
SCHEMBL17987883 0.78 HSP90AA1 (0.50) HSP90AA1DYRK1AMAOAMAOBALDH1A1
SCHEMBL17987824 0.77 HSP90AA1 (0.59) HSP90AA1MAOAMAOBALDH1A1CYP1A2
SCHEMBL6715550 0.75 KMT2A (0.67) HSP90AA1MAOAMAOBALDH1A1PAX8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018081612-A1 COMPOUNDS AND METHODS FOR TREATING CANCER ACTAVALON, INC. (US) 2018-05-03 WO disclosed