Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.59 |
| ▸ | RAB9A | P51151 | 12/20 | 0.59 |
| ▸ | NPC1 | O15118 | 10/20 | 0.59 |
| ▸ | MAPT | P10636 | 9/20 | 0.59 |
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | USP2 | O75604 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | AR | P10275 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24330005 | 0.84 | RAB9A (0.58) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL9963514 | 0.81 | RAB9A (0.74) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL20101017 | 0.81 | NPC1 (0.48) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL30611157 | 0.78 | LRRK2 (0.46) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL30611161 | 0.78 | CYP2D6 (0.46) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL24330007 | 0.78 | CYP2D6 (0.46) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL24330008 | 0.78 | LRRK2 (0.46) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL21588444 | 0.75 | RAB9A (0.58) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL16896300 | 0.75 | KCNH2 (0.62) | SMN1; SMN2RAB9ANPC1MAPTTP53 | |
| SCHEMBL24359018 | 0.75 | RAB9A (0.66) | SMN1; SMN2RAB9ANPC1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081612-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER | ACTAVALON, INC. (US) | 2018-05-03 | — | — | WO | disclosed |