Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17954207 | 0.80 | PRF1 (0.37) | PRF1ACHEROCK2ROCK1AKR1B1 | |
| SCHEMBL17954215 | 0.75 | MAOB (0.48) | ROCK2 | |
| SCHEMBL17954212 | 0.74 | AKR1B1 (0.40) | PRF1ACHEROCK2AKR1B1 | |
| SCHEMBL20216036 | 0.72 | ROCK2 (0.38) | PRF1ACHEROCK2ROCK1AKR1B1 | |
| SCHEMBL18165309 | 0.71 | FFAR1 (0.51) | AKR1B1 | |
| SCHEMBL20788480 | 0.70 | AKR1B1 (0.56) | PRF1ACHEROCK2ROCK1AKR1B1 | |
| SCHEMBL803505 | 0.70 | KCNJ1 (0.43) | ROCK2ROCK1AKR1B1KCNJ1KCNH2 | |
| SCHEMBL30529078 | 0.70 | AKR1B1 (0.56) | PRF1ACHEROCK2ROCK1AKR1B1 | |
| SCHEMBL16624701 | 0.69 | ROCK2 (0.38) | ROCK2ROCK1 | |
| SCHEMBL17954236 | 0.69 | ROCK2 (0.39) | ROCK2ROCK1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052107-B1 | ORGANIC COMPOUNDS TO TREAT HEPATITIS B VIRUS | NOVARTIS AG (CH) | 2018-05-02 | — | — | EP | disclosed |