Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 5/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15793557 | 0.87 | TDP1 (0.59) | TDP1HTTL3MBTL1KMT2APOLB | |
| SCHEMBL15793556 | 0.87 | TDP1 (0.59) | TDP1HTTL3MBTL1KMT2APOLB | |
| SCHEMBL15793288 | 0.86 | TDP1 (0.56) | TDP1HTTL3MBTL1KMT2APOLB | |
| SCHEMBL15793286 | 0.86 | TDP1 (0.56) | TDP1HTTL3MBTL1KMT2APOLB | |
| SCHEMBL15793304 | 0.86 | HTT (0.55) | TDP1HTTL3MBTL1KMT2APOLB | |
| SCHEMBL15793536 | 0.86 | HTT (0.55) | TDP1HTTL3MBTL1KMT2APOLB | |
| SCHEMBL19518906 | 0.83 | KMT2A (0.41) | TDP1HTTL3MBTL1KMT2APOLB | |
| SCHEMBL17826311 | 0.78 | ELANE (0.51) | TDP1HTTL3MBTL1KMT2APOLB | |
| SCHEMBL17343235 | 0.78 | KMT2A (0.58) | TDP1HTTL3MBTL1KMT2APOLB | |
| SCHEMBL17311384 | 0.77 | ELANE (0.58) | TDP1HTTL3MBTL1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154977-B1 | NOVEL COMPOUNDS | CHIESI FARM SPA (IT) | 2018-05-02 | — | — | EP | disclosed |