Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 7/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.41 |
| ▸ | IGF1R | P08069 | 4/20 | 0.41 |
| ▸ | KIT | P10721 | 5/20 | 0.36 |
| ▸ | FLT3 | P36888 | 4/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848144 | 0.93 | INSR (0.40) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL20102201 | 0.88 | INSR (0.38) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL20110289 | 0.86 | INSR (0.57) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL20102203 | 0.86 | ALK (0.45) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL20102209 | 0.85 | ALK (0.48) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL17848233 | 0.81 | INSR (0.37) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL17848096 | 0.80 | ALK (0.44) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL17848119 | 0.79 | ALK (0.47) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL590635 | 0.77 | ALK (0.39) | INSRALKIGF1RKITFLT3 | |
| SCHEMBL591724 | 0.77 | ALK (0.40) | INSRALKIGF1RKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | UNVERSITA' DEGLI STUDI DI MILANO (IT) | 2018-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180118691-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | MAP4K2, MAP3K20, MAPKAPK2 | INSR 2001/4885ALK 2551/4885IGF1R 890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.