Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9406310 | 0.77 | ESR2 (0.39) | ESR2CCNT1CDK9TRPV1BACE1 | |
| SCHEMBL10929197 | 0.77 | ESR2 (0.73) | ESR2CYP3A4CYP2C9BACE1DRD2 | |
| SCHEMBL20103345 | 0.76 | CDK9 (0.49) | KMT2AMEN1KDM4EALDH1A1HPGD | |
| SCHEMBL10932682 | 0.76 | ESR2 (0.71) | ESR2KDM1ABACE1DRD2DRD4 | |
| SCHEMBL9419292 | 0.76 | ESR2 (0.40) | ESR2GLAKMT2ALMNAPMP22 | |
| SCHEMBL20103515 | 0.76 | ESR2 (0.47) | ESR2CCNT1CDK9 | |
| SCHEMBL9419278 | 0.74 | CCNT1 (0.36) | ESR2MAPK1CCNT1CDK9BACE1 | |
| SCHEMBL20103296 | 0.72 | ESR2 (0.46) | ESR2MAPTCCNT1CDK9KDM1A | |
| SCHEMBL13263148 | 0.72 | ESR2 (0.40) | ESR2GLAKMT2ALMNAPMP22 | |
| SCHEMBL2259517 | 0.72 | CYP11B1 (0.39) | ESR2CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018081047-A1 | CYCLOHEXYL GPR40 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-03 | — | — | WO | disclosed |