Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18208689 | 0.84 | HSD11B1 (0.51) | HSD11B1ALDH1A1EGLN1LIPEALOX5 | |
| SCHEMBL20185049 | 0.84 | HSD11B1 (0.51) | HSD11B1HTR7ALDH1A1EGLN1LIPE | |
| SCHEMBL549209 | 0.83 | HSD11B1 (0.46) | HSD11B1HTR7HTR1AADRA1BL3MBTL1 | |
| Hydrochloric Acid SCHEMBL2699664 | 0.82 | HSD11B1 (0.45) | HSD11B1HTR7ALDH1A1TSHREGLN1 | |
| Hydrochloric Acid SCHEMBL5568924 | 0.82 | HSD11B1 (0.45) | HSD11B1HTR7ALDH1A1TSHREGLN1 | |
| Hydrochloric Acid SCHEMBL550274 | 0.82 | HSD11B1 (0.45) | HSD11B1HTR7ALDH1A1TSHREGLN1 | |
| SCHEMBL12654777 | 0.81 | KMT2A (0.50) | HTR1AADRA1BEGLN1ADRA1A | |
| Hydrochloric Acid SCHEMBL5568920 | 0.80 | HSD11B1 (0.43) | HSD11B1HTR7HTR1AADRA1BTSHR | |
| SCHEMBL3700174 | 0.80 | HSD11B1 (0.46) | HSD11B1EGLN1ALB | |
| SCHEMBL2703017 | 0.80 | HSD11B1 (0.46) | HSD11B1EGLN1ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018078005-A1 | AMIDO-SUBSTITUTED AZASPIRO DERIVATIVES AS TANKYRASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-03 | — | — | WO | disclosed |